P1 (Stehle)
Retargeting and Inhibition of Glycan-Binding Polyomaviruses
In this project, we will determine crystal structures of newly emerging polyomaviruses and structurally and functionally characterize their receptor-binding properties. A major emphasis of this work will be on determining parameters that modulate receptor binding and entry, and on developing strategies that can interfere with binding. P1 will therefore rely heavily on expertise in virus uptake (P4) and ligand design (P7), as well as on the characterization of structural changes and affinities (P8). This project will also rely on expertise in VLP characterization (P3) and affinity measurements by NMR spectroscopy (P6).
